B3.i Classify and describe adverse drug reactions.
B3.ii Classify and describe mechanisms of drug interactions.
B3.iii Describe variability in drug responses due to physiological changes with reference to the following:
B3.iii.a extremes of age (neonates, pediatrics and the elderly),
B3.iii.b extremes of body size (obesity),
B3.iii.c pregnancy including parturition and foetal,
B3.iii.d critical illness including sepsis, respiratory, cardiac, liver and renal failure
B3.iv Define tachyphylaxis, tolerance, addiction, dependence and idiosyncrasy.
B3.v Describe the mechanisms of tolerance.
B3.vi Outline the relevance of genetics to variability of drug response including the significance of the following pharmacogenetic disorders:
B3.vi.a malignant hyperthermia,
B3.vi.b atypical cholinesterase.
B3.vii Explain isomerism and its clinical importance with examples.