B2.i With respect to receptor theory, explain the concepts of drug action, including the following:
B2.i.a law of mass action
B2.i.b affinity
B2.i.c association and dissociation constants
B2.ii Explain drug actions with respect to the following:
B2.ii.a enzyme interactions
B2.ii.b physico-chemical interactions
B2.ii.c receptor interactions, including:
B2.ii.c.i ion channels and fluxes
B2.ii.c.ii second messengers and G-proteins
B2.ii.c.iii nucleic acid synthesis
B2.ii.c.iv regulation of receptor number and activity
B2.ii.c.v structural relationships between receptors and ligands
B2.iii Define and explain dose-effect relationships of drugs, including dose-response curves, with reference to:
B2.iii.a graded and quantal response
B2.iii.b therapeutic index and therapeutic window
B2.iii.c intrinsic activity, potency and efficacy and their relevance to:
B2.iii.c.i agonists
B2.iii.c.ii competitive and non-competitive antagonists
B2.iii.c.iii partial agonists
B2.iii.c.iv mixed agonist-antagonists
B2.iii.c.v inverse agonists